Brain chemicals also (known as neurotransmitters) serotonin, dopamine and norepinephrine are theorized to be depleted in the brain of individuals suffering from various mental disorders including depression, anxiety and insomnia. Vitamins B6, B9 (folate) and B12 all are very important in the support and synthesis of these neurotransmitters. As a result, low levels of these B vitamins are believed to be linked to a depressed mood. Studies showed that people suffering from depression have lower blood levels of B-vitamin, folate. In fact, nutritionists recommend you get at least 400 mcg of folate every day if you suffer from depression. Conventional prescriptive approaches including SSRIs, SNRIs , DNRIS , benzodiazepines, and tricyclics, though effective, pose undesirable potential side effects including decreased libido and sexual performance, gastrointestinal distress, weight gain and emotional numbing. Complementary and Integrative therapy for PTSD, anxiety and depression focus on replenishing these micronutrient imbalances or by saturating the central nervous system with amino acids and vitamins , particularly B vitamins, with hopes of increasing neurotransmitter synthesis of norepinephrine, serotonin and dopamine.